Conserved Site

Aldose 1-epimerase, conserved site (IPR018052)

Short name: Ald1_epimerase_CS


Aldose 1-epimerase (EC: (mutarotase) is the enzyme responsible for the anomeric interconversion of D-glucose and other aldoses between their alpha- and beta-forms.

The sequence of mutarotase from two bacteria, Acinetobacter calcoaceticus and Streptococcus thermophilus is available [PMID: 1694527]. It has also been shown that, on the basis of extensive sequence similarities, a mutarotase domain seems to be present in the C-terminal half of the fungal GAL10 protein which encodes, in the N-terminal part, UDP-glucose 4-epimerase.

The entry represents a conserved site of aldose 1-epimerase, which is centred around a conserved histidine residue and may be involved in the catalytic mechanism.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns