Conserved Site

Phosphomannose isomerase, type I, conserved site (IPR018050)

Short name: Pmannose_isomerase-type1_CS


Phosphomannose isomerase (PMI) [PMID: 8307007, PMID: 8260497] is the enzyme that catalyzes the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes, it is involved in the synthesis of GDP-mannose which is a constituent of N- and O-linked glycans as well as GPI anchors. In prokaryotes, it is involved in a variety of pathways including capsular polysaccharide biosynthesis and D-mannose metabolism.

Three classes of PMI have been defined on the basis of sequence similarities [PMID: 8307007]. The first class comprises all known eukaryotic PMI as well as the enzyme encoded by the manA gene in enterobacteria such as Escherichia coli. Class I PMI's are proteins of about 42 to 50 kDa which bind a zinc ion essential for their activity.

Two conserved regions define class I PMI. The first one is located in the N-terminal section of the proteins, the second in the C-terminal half. Both patterns contain a residue involved in the binding of the zinc ion [PMID: 8612079].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004476 mannose-6-phosphate isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns