Conserved Site

Pili assembly chaperone, conserved site (IPR018046)

Short name: Pili_assmbl_chaperone_CS


Most Gram-negative bacteria possess a supramolecular structure - the pili - on their surface, which mediates attachment to specific receptors. Many interactive subunits are required to assemble pili, but their assembly only takes place after translocation across the cytoplasmic membrane. Periplasmic chaperones assist pili assembly by binding to the subunits, thereby preventing premature aggregation [PMID: 8670884, PMID: 1683764]. Pili chaperones are structurally, and possibly evolutionarily, related to the immunoglobulin superfamily [PMID: 1348692, PMID: 17082819]: they contain two globular domains, with a topology identical to an immunoglobulin fold [PMID: 2478891].

This entry represents a highly conserved region located in the C-terminal section of the first globular domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns