Conserved Site

Sulphate anion transporter, conserved site (IPR018045)

Short name: S04_transporter_CS

Description

A number of proteins involved in the transport of sulphate across a membrane as well as some yet uncharacterised proteins have been shown [PMID: 8140616, PMID: 7616962] to be evolutionary related. These proteins are:

  • Neurospora crassa sulphate permease II (gene cys-14).
  • Yeast sulphate permeases (genes SUL1 and SUL2).
  • Rat sulphate anion transporter 1 (SAT-1).
  • Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).
  • Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.
  • Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.
  • Human protein DRA (Down-Regulated in Adenoma).
  • Soybean early nodulin 70.
  • Escherichia coli hypothetical protein ychM.
  • Caenorhabditis elegans hypothetical protein F41D9.5.

These proteins are highly hydrophobic and seem to contain about 12 transmembrane domains.

GO terms

Biological Process

GO:0008272 sulfate transport

Molecular Function

GO:0008271 secondary active sulfate transmembrane transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns