Conserved Site

Aspartate kinase, conserved site (IPR018042)

Short name: Aspartate_kinase_CS


Aspartate kinase (EC: (AK) catalyzes the first reaction in the aspartate pathway; the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine [PMID: 2892836].

In bacteria there are three different aspartate kinase isozymes which differ in sensitivity to repression and inhibition by Lys, Met and Thr. AK1 and AK2 are bifunctional enzymes which both consist of an N-terminal AK domain and a C-terminal homoserine dehydrogenase domain. AK1 is involved in threonine biosynthesis and AK2, in that of methionine. The third isozyme, AK3 is monofunctional and involved in lysine synthesis. In archaea and plants there may be a single isozyme of AK which in plants is multifunctional.

This entry represents a region encoding aspartate kinase activity found in both the monofunctional and bifunctional enzymes.

Synonym(s): Aspartokinase

GO terms

Biological Process

GO:0008652 cellular amino acid biosynthetic process

Molecular Function

GO:0004072 aspartate kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns