D-aminoacyl-tRNA deacylase, archaea (IPR018033)

Short name: Deacylase_DtdA_archaea

Overlapping homologous superfamilies


Family relationships


D-aminoacyl-tRNA deacylases hydrolyse the ester bond between the polynucleotide and the D-amino acid, thereby preventing the accumulation of such mis-acylated and metabolically inactive tRNA molecules. Several aminoacyl-tRNA synthetases have the ability to transfer the D-isomer of their amino acid onto their cognate tRNA [PMID: 16844682, PMID: 17251192].

This entry represents a group of Archaeal D-aminoacyl-tRNA deacylases (also known as d-Tyr- tRNA(Tyr) deacylases) that shares homology with plant D-aminoacyl-tRNA deacylase. The expression of plant D-aminoacyl-tRNA deacylase is capable of functionally compensating in E. coli for the absence of endogeneous d-Tyr- tRNA(Tyr) deacylase [PMID: 17251192].

GO terms

Biological Process

GO:0019478 D-amino acid catabolic process

Molecular Function

GO:0051499 D-aminoacyl-tRNA deacylase activity
GO:0016788 hydrolase activity, acting on ester bonds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.