Conserved Site

Fimbrial membrane usher, conserved site (IPR018030)

Short name: Fimbrial_membr_usher_CS

Description

In Gram-negative bacteria the biogenesis of fimbriae (or pili) requires a two- component assembly and transport system which is composed of a periplasmic chaperone (see PDOC00552) and an outer membrane protein which has been termed a molecular 'usher' [PMID: 7909802, PMID: 7906265, PMID: 7906046].

The usher protein is rather large (from 86 to 100 Kd) and seems to be mainly composed of membrane-spanning beta-sheets, a structure reminiscent of porins. Although the degree of sequence similarity of these proteins is not very high they share a number of characteristics. One of these is the presence of two pairs of cysteines, the first one located in the N-terminal part and the second at the C-terminal extremity that are probably involved in disulphide bonds. The best conserved region is located in the central part of these proteins.

This entry represents the conserved site of the Fimbrial biogenesis outer membrane usher protein.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns