Conserved Site

Ribosome maturation protein SBDS, conserved site (IPR018023)

Short name: Ribosome_mat_SBDS_CS

Description

Proteins identified by this conserved site are involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes in eukaryotes. Together with the EF-2-like GTPase RIA1, they may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns