Vinculin (IPR017997)

Short name: Vinculin

Overlapping homologous superfamilies


Family relationships


Vinculin is an actin filament (F-actin) binding protein involved in cell-matrix adhesion and cell-cell adhesion [PMID: 2112986]. In addition to actin, vinculin interacts with other structural proteins such as talin and alpha-actinins [PMID: 28401269].

Vinculin is a large protein of 116 kDa (about a 1000 residues). Structurally the protein consists of an acidic N-terminal domain of about 90 kDa separated from a basic C-terminal domain of about 25 kDa by a proline-rich region of about 50 residues. The central part of the N-terminal domain consists of a variable number (3 in vertebrates, 2 in Caenorhabditis elegans) of repeats of a 110 amino acids domain. Interestingly, vinculin exists in two conformations in the cell: an open, active form and a closed, auto-inhibited state in which the head domain forms extensive interactions with the tail [PMID: 28401269].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.