Conserved Site

DNA methylase, N-4 cytosine-specific, conserved site (IPR017985)

Short name: MeTrfase_CN4_CS


Synonym(s): N-4 cytosine-specific DNA methylase, Modification methylase

Site-specific DNA-methyltransferase (cytosine-N4-specific) (EC: are enzymes that specifically methylate the amino group at the C-4 position of cytosines in DNA. In prokaryotes, the major role of DNA methylation is to protect host DNA against degradation by restriction enzymes. There are two major classes of DNA methyltransferase that differ in the nature of the modifications they effect. The members of one class (C-MTases) methylate a ring carbon and form C5-methylcytosine and members of the second class (N-MTases) methylate exocyclic nitrogens and form either N4-methylcytosine (N4-MTases) or N6-methyladenine (N6-MTases). Both classes of MTase utilise the cofactor S-adenosyl-L-methionine (SAM) as the methyl donor and are active as monomeric enzymes [PMID: 7663118].

GO terms

Biological Process

GO:0090124 N-4 methylation of cytosine

Molecular Function

GO:0003677 DNA binding
GO:0015667 site-specific DNA-methyltransferase (cytosine-N4-specific) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns