Conserved Site

Heavy-metal-associated, conserved site (IPR017969)

Short name: Heavy-metal-associated_CS


Proteins that transport heavy metals in micro-organisms and mammals share similarities in their sequences and structures.

These proteins provide an important focus for research, some being involved in bacterial resistance to toxic metals, such as lead and cadmium, while others are involved in inherited human syndromes, such as Wilson's and Menke's diseases [PMID: 8091505].

A conserved domain has been found in a number of these heavy metal transport or detoxification proteins [PMID: 8091505]. The domain, which has been termed Heavy-Metal-Associated (HMA), contains two conserved cysteines that are probably involved in metal binding.

Structure solution of the fourth HMA domain of the Menke's copper transporting ATPase shows a well-defined structure comprising a four-stranded antiparallel beta-sheet and two alpha helices packed in an alpha-beta sandwich fold [PMID: 9437429]. This fold is common to other domains and is classified as "ferredoxin-like".

GO terms

Biological Process

GO:0030001 metal ion transport

Molecular Function

GO:0046872 metal ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns