Domain

DNA-repair protein, UmuC-like, N-terminal (IPR017963)

Short name: DNA_repair_prot_UmuC-like_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of UmuC-like DNA repair proteins. In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. This machinery allows the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage [PMID: 9560379]. UmuC is a well conserved protein in prokaryotes, with a homologue in yeast species.

Proteins currently known to belong to this family are listed below:

  • E. coli MucB protein. Plasmid-born analogue of the UmuC protein.
  • Saccharomyces cerevisiae (Baker's yeast) Rev1 protein. Homologue of UmuC also required for normal induction of mutations by physical and chemical agents.
  • Salmonella typhimurium ImpB protein. Plasmid-born analogue of the UmuC protein.
  • Bacterial UmuC protein.
  • E. coli DNA-damage-inducible protein P (DinP).
  • S. typhimurium SamB homologue of UmuC plasmid associated.

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003887 DNA-directed DNA polymerase activity
GO:0003684 damaged DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles