DNA-repair protein, UmuC-like, N-terminal (IPR017963)
Short name: DNA_repair_prot_UmuC-like_N
This entry represents the N-terminal domain of UmuC-like DNA repair proteins. In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. This machinery allows the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage [PMID: 9560379]. UmuC is a well conserved protein in prokaryotes, with a homologue in yeast species.
Proteins currently known to belong to this family are listed below:
- E. coli MucB protein. Plasmid-born analogue of the UmuC protein.
- Saccharomyces cerevisiae (Baker's yeast) Rev1 protein. Homologue of UmuC also required for normal induction of mutations by physical and chemical agents.
- Salmonella typhimurium ImpB protein. Plasmid-born analogue of the UmuC protein.
- Bacterial UmuC protein.
- E. coli DNA-damage-inducible protein P (DinP).
- S. typhimurium SamB homologue of UmuC plasmid associated.
- PS50173 (UMUC)