Conserved Site

Lipid-binding serum glycoprotein, conserved site (IPR017954)

Short name: Lipid-bd_serum_glycop_CS

Description

This entry represents a conserved sequence region found in the N-terminal domain of several lipid-binding serum glycoproteins. The N- and C-terminal domains of these proteins share a similar two-layer alpha/beta structure, but they show little sequence identity. Proteins containing this N-terminal domain include:

  • Bactericidal permeability-increasing protein (BPI)
  • Lipopolysaccharide-binding protein (LBP)
  • Cholesteryl ester transfer protein (CETP)
  • Phospholipid transfer protein (PLTP)
  • Palate, lung and nasal epithelium carcinoma-associated protein (PLUNC)

Bactericidal permeability-increasing protein (BPI) is a potent antimicrobial protein of 456 residues that binds to and neutralises lipopolysaccharides from the outer membrane of Gram-negative bacteria [PMID: 9188532]. BPI contains two domains that adopt the same structural fold, even though they have little sequence similarity [PMID: 10843855].

Lipopolysaccharide-binding protein (LBP) is an endotoxin-binding protein that is closely related to BPI, and functions with it to facilitate an integrated host response to invading Gram-negative bacteria [PMID: 12887306].

Cholesteryl ester transfer protein (CETP) is a glycoprotein that facilitates the transfer of lipids (cholesteryl esters and triglycerides) between the different lipoproteins that transport them through plasma, including HDL, LDL, VLDL and chylomicrons. These lipoproteins shield the lipids from water by encapsulating them within a coating of polar lipids and proteins [PMID: 17277799].

Phospholipid transfer protein (PLTP) exchanges phospholipids between lipoproteins and remodels high-density lipoproteins (HDLs) [PMID: 12693940].

Palate, lung and nasal epithelium carcinoma-associated protein (PLUNC) is a potential host defensive protein that is secreted from the submucosal gland to the saliva and nasal lavage fluid. PLUNC aapears to be a secreted product of neutrophil granules that participates in an aspect of the inflammatory response that contributes to host defence [PMID: 18245229]. Short palate, lung and nasal epithelium clone 1 (SPLUNC1) may bind the lipopolysaccharide of Gram-negative nanobacteria, thereby playing an important role in the host defence of nasopharyngeal epithelium [PMID: 16364440].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008289 lipid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns