Homologous Superfamily

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily (IPR017946)

Short name: PLC-like_Pdiesterase_TIM-brl

Overlapping entries


This superfamily represents a structural domain consisting of a TIM beta/alpha-barrel. These domains are found in several phospholipase C (PLC) like phosphodiesterases, including:

  • Mammalian phospholipase C isozyme D1 [PMID: 8784353].
  • Bacterial phosphatidylinositol-specific phospholipase C [PMID: 9335537].
  • Glycerophosphodiester phosphodiesterases, such as GlpQ from Escherichia coli and UgpQ from Agrobacterium tumefaciens [PMID: 16909422].

Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. PLC enzymes often play central roles in various signalling cascades [PMID: 18691970].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

GO:0008081 phosphoric diester hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.