Domain

DBB domain (IPR017893)

Short name: DBB_domain

Domain relationships

None.

Description

This entry represents the DBB domain.

The following proteins share a number of distinct parts, namely with ankyrin repeats (see PDOC50088), a coiled coil, and a stretch of approximately 140 amino acid residues the development of the immune system in higher upstream of the ankyrin repeats, which has been called the Dof/BCAP/BANK (DBB) domain [PMID: 12767830, PMID: 14993266]:

  • Drosophila Downstream-of-EGF receptor (Dof), a protein essential for the morphogenesis of both the mesoderm and the tracheae. It has been proposed to mediate the transmission of a signal from an activated receptor to other components of the cell, including the MAP kinase cascade.
  • Vertebrate BANK and BCAP proteins that function in B-cell signalling.

These proteins are involved in signalling; however, unlike Dof, BANK and BCAP are not implicated in FGF signalling but appear to have undergone rapid change during the course of evolution to acquire a novel function with vertebrates.

The DBB domain in both Dof and BCAP is required to mediate self-association in yeast cells, indicating that this domain may have a more general role in mediating protein-protein interactions [PMID: 12767830].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam