CRIC domain (IPR017874)

Short name: CRIC_domain

Overlapping homologous superfamilies


Domain relationships



The multi-domain protein Connector enhancer of kinase suppressor of ras (Connector enhancer of KSR) (CNK) functions as a scaffold in several signal cascades and acts on proliferation, differentiation and apoptosis. CNK connects upstream activators and downstream targets of Ras- and Rho-dependent signalling pathways and may allow cross-talk between these pathways. In invertebrates, CNK is expressed as one isoform, whereas in mammals there exists CNK1, CNK2A, and its splice variant CNK2B. CNK proteins consist of one sterile alpha motif (SAM) domain (see PDOC50105, IPR001660) one conserved region in CNK (CRIC) domain, one PSD-96/Dlg-A/ZO-1 (PDZ) domain (see PDOC50106, IPR001478) and one pleckstrin homology (PH) domain (see PDOC50003, IPR001849. The CRIC domain is enriched in leucine residues and functions as a protein-protein interaction domain [PMID: 12028359, PMID: 16289034].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles