Repeat

Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote (IPR017873)

Short name: Cys-rich_GLG1_repeat_euk

Description

This entry is found in Golgi apparatus protein 1 (GLG1,Q9Z1E9) and related proteins in the metazoa. GLG1 is located in Golgi cisterns of various cell types, can bind fibroblast growth factor and E-selectin. Sixteen cysteine-rich GLG1 repeats form the core of the protein and are located in the lumen. The C-terminal part of GLG1 is composed of a transmembrane region and a short cytoplasmic tail. The Cys-rich GLG1 repeat is a ~60 amino acid module that contains 4 Cys residues, which can form intrachain disulphide bridges [PMID: 1448090]. Homologues of the vertebrate GLG1/Golgi sialoglycoprotein MG-160 (Mg160)/E-selectin ligand 1 (ESL1)/cysteine-rich fibroblast growth factor receptor 1 (CFR1)/latent transforming growth factor-beta complex protein 1 (LTCP-1) have been found in insects and the nematode Caenorhabditis elegans [PMID: 12029485].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000139 Golgi membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles