SKI-interacting protein, SKIP (IPR017862)

Short name: SKI-int_prot_SKIP

Overlapping homologous superfamilies


Family relationships



SKIP (SKI-interacting protein) is an essential spliceosomal component and transcriptional coregulator, which may provide regulatory coupling of transcription initiation and splicing [PMID: 15052407]. SKIP was identified in a yeast 2-hybrid screen, where it was shown to interact with both the cellular and viral forms of SKI through the highly conserved region on SKIP known as the SNW domain [PMID: 11522815]. SKIP is now known to interact with a number of other proteins as well. SKIP potentiates the activity of important transcription factors, such as vitamin D receptor, CBF1 (RBP-Jkappa), Smad2/3, and MyoD. It works with Ski in overcoming pRb-mediated cell cycle arrest, and it is targeted by the viral transactivators EBNA2 and E7 [PMID: 10644367].

GO terms

Biological Process

GO:0000398 mRNA splicing, via spliceosome

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005681 spliceosomal complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.