Conserved Site

Peptidase M22, conserved site (IPR017860)

Short name: Peptidase_M22_CS

Description

Glycoprotease (Gcp) (EC:3.4.24.57) [PMID: 1885539], or o-syaloglycoprotein endopeptidase, is a metalloprotease secreted by Pasteurella haemolytica which specifically cleaves O-sialoglycoproteins such as glycophorin A. It belongs to the peptidase family M22. The sequence of Gcp is highly similar to uncharacterised orthologues in most complete genomes of bacteria and archaebacteria as well as in yeast (QRI7 and YKR038c).

This entry represents a conserved site found in proteins classified as M22 peptidases, though there is a lack of experimental evidence to support peptidase activity as a general property of this family. This site contains two conserved histidines. It is possible that this region is involved in coordinating a metal ion such as zinc.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns