Domain

Integrase, N-terminal zinc-binding domain-like (IPR017856)

Short name: Integrase_Zn-bd_dom-like_N

Domain relationships

Description

This entry represents a structural domain with an alpha-helical, orthogonal bundle fold. Domains with this structure are found at the N-terminal (zinc-binding domain) of HIV integrase, and in the following hypothetical proteins: YebC from Escherichia coli, HP0162 from Helicobacter pylori (Campylobacter pylori) and aq1575 from Aquifex aeolicus [PMID: 12060744].

Retroviral integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains: an N-terminal zinc binding domain, a central catalytic core and a C-terminal DNA-binding domain [PMID: 11743009, PMID: 11101216]. It is often found as part of the POL polyprotein.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D