Glutamate--cysteine ligase EgtA, Actinobacteria (IPR017809)

Short name: EgtA_Actinobacteria

Overlapping homologous superfamilies

Family relationships


Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and gamma-L-glutamyl-L-cysteine suggests that this enzyme is a bone fide glutamate--cysteine ligase [PMID: 20420449].

GO terms

Biological Process

GO:0052699 ergothioneine biosynthetic process

Molecular Function

GO:0004357 glutamate-cysteine ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.