Family

Hydroxyacylglutathione hydrolase (IPR017782)

Short name: Hydroxyacylglutathione_Hdrlase

Family relationships

None.

Description

This entry represents hydroxyacylglutathione hydrolase, a detoxification enzyme also known as glyoxalase II. It follows lactoylglutathione lyase, also known as glyoxalase I, and acts to remove the toxic metabolite methylglyoxal and related compounds. This protein belongs to the broader metallo-beta-lactamase family [PMID: 17196158, PMID: 10882093].

GO terms

Biological Process

GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Molecular Function

GO:0004416 hydroxyacylglutathione hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
HAMAP
PIRSF