2,3-diketo-5-methylthiopentyl-1-phosphate enolase (IPR017717)

Short name: Diketo-Methiopentyl-P_enolase

Overlapping homologous superfamilies

Family relationships

  • RuBisCO (IPR033966)
    • 2,3-diketo-5-methylthiopentyl-1-phosphate enolase (IPR017717)


Members of this family are the methionine salvage pathway enzyme 2,3-diketo-5-methylthiopentyl-1-phosphate enolase, a homologue of RuBisCO [PMID: 19279009, PMID: 14551435]. They catalyze the tautomerization of 2,3-diketo-5-methylthiopentane 1-phosphate (DK-MTP 1-P). This is an important step in the methionine salvage pathway in which 5-methylthio-D-ribose (MTR) derived from 5'-methylthioadenosine is converted to methionine. This protein family seems restricted to Bacillus subtilis and close relatives, where two separate proteins carry the enolase and phosphatase activities that in other species occur in a single protein, MtnC (IPR023943).

GO terms

Biological Process

GO:0019509 L-methionine salvage from methylthioadenosine

Molecular Function

GO:0043715 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.