Coenzyme F420 hydrogenase, subunit beta (IPR017679)

Short name: Coenz_F420_hydrogenase_bsu

Overlapping homologous superfamilies


Family relationships



This entry represents the beta subunit of coenzyme F420 hydrogenase (FRH) (EC: found exclusively and universally in methanogenic archaea [PMID: 2207102]. Active coenzyme F420 hydrogenase forms a heterocomplex of three subunits: alpha (IPR017682), beta and gamma (IPR017681). This enzyme reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. The enzyme complex is tightly associated with the redox cofactors: nickel, flavin adenine dinucleotide (FAD), and iron-sulphur cluster (2-13 Fe atoms per alpha/beta/gamma unit of the FRH) [PMID: 3663585].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0050454 coenzyme F420 hydrogenase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0051536 iron-sulfur cluster binding
GO:0016151 nickel cation binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.