5-dehydro-4-deoxyglucarate dehydratase (IPR017655)

Short name: Dehydro-deoxyglucarate_dehyd

Overlapping homologous superfamilies

Family relationships

  • DapA-like (IPR002220)
    • 5-dehydro-4-deoxyglucarate dehydratase (IPR017655)


5-dehydro-4-deoxyglucarate dehydratase (also called 5-keto-4-deoxy-glucarate dehydratase or KDGDH), is a member of the same family as dihydrodipicolinate synthase (DHDPS) [PMID: 11031117]. 5-dehydro-4-deoxyglucarate dehydratase is involved in glucarate metabolism, where it catalyses the dehydration and decarboxylation of 5-dehydro-4-deoxy-D-glucarate to 2,5-dioxopentanoate [PMID: 4982840]. In certain species of Enterobacteriaceae 5-dehydro-4-deoxy-D-glucarate is degraded to pyruvate and glycerate, instead of to 2,5-dioxopentanoate [PMID: 4311826].

GO terms

Biological Process

GO:0016052 carbohydrate catabolic process

Molecular Function

GO:0047448 5-dehydro-4-deoxyglucarate dehydratase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.