3-oxoacyl-[acyl-carrier-protein] synthase 2 (IPR017568)

Short name: 3-oxoacyl-ACP_synth-2

Overlapping homologous superfamilies

Family relationships



3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein [PMID: 11152607]. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common [PMID: 16441657]. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis ((GenProp0681). The large gap between the trusted cut-off and the noise cut-off contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cut-off of this model.

GO terms

Biological Process

GO:0006633 fatty acid biosynthetic process

Molecular Function

GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.