Family

3-hexulose-6-phosphate isomerase (IPR017552)

Short name: PHI/rmpB

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

6-phospho 3-hexuloisomerase (PHI, also known as rmpB) is part of the ribulose monophosphate (RuMP) pathway, which in one direction removes the toxic metabolite formaldehyde by assimilation into fructose-6-phosphate [PMID: 10648518]. In the other direction, in species lacking a complete pentose phosphate pathway, the RuMP pathway yields ribulose-5-phosphate, necessary for nucleotide biosynthesis, at the cost of also yielding formaldehyde. These latter species tend usually have a formaldehyde-activating enzyme to attach formaldehyde to the C1 carrier tetrahydromethanopterin.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016853 isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PANTHER
TIGRFAMs