Glycine cleavage system H-protein, subgroup (IPR017453)

Short name: GCV_H_sub

Overlapping homologous superfamilies

Family relationships


This is a family of glycine cleavage H-proteins, part of the glycine cleavage system (GCS) found in bacteria, archaea, and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine [PMID: 11286922]. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue [PMID: 8197146].

This entry represents the glycine cleavage system H protein. The genome of Aquifex aeolicus contains one protein belonging to this group, and four more related proteins not included here; it seems doubtful that all of these homologues are authentic H proteins. The Chlamydial homologue of the H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, and is not included in this entry.

GO terms

Biological Process

GO:0019464 glycine decarboxylation via glycine cleavage system

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005960 glycine cleavage complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.