Interferon regulatory factor-1/2 (IPR017431)

Short name: IRF1/IRF2

Overlapping homologous superfamilies


Family relationships


This entry represents the interferon regulatory factor 1/2.

IRF1 is a transcriptional regulator involved in the regulation of several cellular responses, such as regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage [PMID: 15226432, PMID: 11244049, PMID: 22200613, PMID: 19851330, PMID: 15509808, PMID: 11846974].

IRF2 is a multifunctional transcription factor that plays a pivotal role in regulation of apoptosis and cell cycle control [PMID: 8438157, PMID: 12738767, PMID: 8713742]. It also plays an important role in modulating cellular responses to interferon (IFN) and viral infection [PMID: 25755403]. It has an antagonistic role to IRF1 in transcriptional regulation of IFN and ISG genes [PMID: 25463511]. While IRF1 acts as a positive regulator, IRF2 is known to repress IFN-mediated gene expression.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.