Mitogen-activated protein (MAP) kinase kinase kinase 7 (IPR017421)

Short name: MAPKKK7

Overlapping homologous superfamilies

Family relationships



This entry represents mitogen-activated protein kinase kinase kinase 7 (MAP3K7), which is a component of a protein kinase signal transduction cascade, acting as a mediator of TGF-beta signal transduction. MAP3K7 stimulates NF-kappa-B (NFKB) activation and the p38 MAPK pathway. MAP3K7 binds both upstream activators and downstream substrates in multi-molecular complexes. It appears to interact with MAP3K7IP1 and MAP3K7IP2, as well as with PPM1L. The interaction of MAP3K7 with PP2A and PPP6C leads to its' repressed activity.

A small deletion of MAP3K7 and four other genes was found to be strongly associated with high-grade prostate cancers [PMID: 17785553].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0004709 MAP kinase kinase kinase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.