Protein phosphatase 1 regulatory subunit 12A/B/C (IPR017401)

Short name: MYPT1/MYPT2/Mbs85

Overlapping homologous superfamilies


Family relationships


This group represents protein phosphatase 1 regulatory subunits 12A/B/C (also known as MYPT1/MYPT2/Mbs85) from animals. They are key regulators of protein phosphatase 1C (PPP1C). They modulates Ca2+-dependent phosphorylation of myosin light chain by myosin light chain kinase, which is essential for smooth muscle contraction [PMID: 24951589, PMID: 16431080]. MYPT2 have similar features as MYPT1, such as: a specific interaction with the catalytic subunit of type 1 phosphatase, delta isoform (PP1cdelta); interaction of MYPT2 with the small heart-specific MP subunit; interaction of the C-terminal region of MYPT2 with the active form of RhoA; phosphorylation by Rho-kinase at an inhibitory site, Thr646 and thiophosphorylation at Thr646 inhibited activity of the MYPT2-PP1cdelta complex [PMID: 16431080]. Mbs85 has been shown to regulate myosin phosphatase activity [PMID: 11399775].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0019208 phosphatase regulator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.