Family

DNA-binding, RFXANK (IPR017362)

Short name: DNA-bd_RFXANK

Family relationships

None.

Description

This group represents the DNA-binding protein RFXANK which activates transcription from class II MHC promoters, requiring the activity of the MHC class II transactivator/CIITA. Deficiency is the commonest cause of bare lymphocyte syndrome (the absence of MHC class II transcription and humoral- and cellular-mediated immune responses to foreign antigens) [PMID: 9806546, PMID: 10072068].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF