Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN (IPR017361)

Short name: Bifunc_PIno_P3_Pase/Pase_PTEN

Overlapping homologous superfamilies


Family relationships



This entry represents the magnesium-dependent bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN (EC:; EC:; EC:, which possesses the following catalytic activities:

  • Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.
  • A phosphoprotein + H(2)O = a protein + phosphate.
  • Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

This protein acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins [PMID: 17324556]. It also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate. The lipid phosphatase activity is critical for its tumour suppressor function [PMID: 18794879]. PTEN antagonizes the PI3K-AKT/PKB signalling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form of PTEN cooperates with AIP1 to suppress AKT1 activation. PTEN dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion form [PMID: 18838554].

GO terms

Biological Process

GO:0046855 inositol phosphate dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0046856 phosphatidylinositol dephosphorylation

Molecular Function

GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.