Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN (IPR017361)
Short name: Bifunc_PIno_P3_Pase/Pase_PTEN
Overlapping homologous superfamilies
This entry represents the magnesium-dependent bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN (EC:188.8.131.52; EC:184.108.40.206; EC:220.127.116.11), which possesses the following catalytic activities:
- Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.
- A phosphoprotein + H(2)O = a protein + phosphate.
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
This protein acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins [PMID: 17324556]. It also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate. The lipid phosphatase activity is critical for its tumour suppressor function [PMID: 18794879]. PTEN antagonizes the PI3K-AKT/PKB signalling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form of PTEN cooperates with AIP1 to suppress AKT1 activation. PTEN dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion form [PMID: 18838554].
GO:0046855 inositol phosphate dephosphorylation
GO:0030336 negative regulation of cell migration
GO:0008285 negative regulation of cell proliferation
GO:0051895 negative regulation of focal adhesion assembly
GO:0051898 negative regulation of protein kinase B signaling
GO:0046856 phosphatidylinositol dephosphorylation
GO:0006470 protein dephosphorylation
GO:0031647 regulation of protein stability
GO:0030165 PDZ domain binding
GO:0000287 magnesium ion binding
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
No terms assigned in this category.
- PIRSF038025 (PTEN)