Chimaerin (IPR017356)

Short name: CHN1/CHN2

Overlapping homologous superfamilies


Family relationships



Chimaerin is a family of GTPase activating proteins for the small G-protein Rac. Chimaerin family members have been implicated in development, neuritogenesis and cancer [PMID: 23673634].

Several isoforms have been found: alpha1-chimaerin (formerly known as n-chimaerin) and alpha2-chimaerin are alternatively spliced products of a single gene, as are beta1- and beta2-chimaerin [PMID: 15507211]. Both alpha-chimaerin isoforms share identical diacylglycerol-binding (C1) and RacGAP domains. Alpha1- and beta1-chimerin have a relatively short N-terminal region that does not encode any recognizable domains, whereas alpha2- and beta2-chimerin both include a functional SH2 domain that can bind to phosphotyrosine motifs within receptors. It has been shown that alpha-chimaerins inactivate Rac and the alpha1-chimaerin isoform contributes to dendritic retraction events in cultured neurons. Alpha2-chimaerin is an effector for EphA4 in cortical and spinal motor circuits [PMID: 17785183]. Beta2-Chimaerin mediates axonal pruning in the hippocampus [PMID: 22726444].

This entry includes alpha-chimaerin (Chn1) and beta-chimaerin (Chn2) from animals.

GO terms

Biological Process

GO:0051056 regulation of small GTPase mediated signal transduction

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.