Family

Vasodilator-stimulated phosphoprotein/ENA/VASP-like (IPR017354)

Short name: VASP/EVL

Overlapping homologous superfamilies

None.

Family relationships

Description

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity, such as axon guidance and lamellipodial and filopodial dynamics in migrating cells [PMID: 14570581, PMID: 11295557]. Ena/VASP proteins possess a modular domain organization, including a conserved tetramerization domain (TD) mediates the formation of Ena/VASP tetramers [PMID: 26221026]. In vertebrates there are three Ena-VASP family members: Mena (Mammalian enabled), VASP, and EVL (Ena-VASP like).

This entry includes VASP and Ena/VASP-like (EVL) proteins.

GO terms

Biological Process

GO:0008154 actin polymerization or depolymerization
GO:0051289 protein homotetramerization

Molecular Function

GO:0017124 SH3 domain binding
GO:0003779 actin binding

Cellular Component

GO:0005856 cytoskeleton

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF