Family

Methyl-CpG binding protein MeCP2 (IPR017353)

Short name: Me_CpG-bd_MeCP2

Family relationships

None.

Description

Methyl-CpG-binding protein 2 (Mecp2) binds specifically to methylated DNA and represses transcription through the recruitment of chromatin remodeling complexes containing histone deacetylase activities [PMID: 9620779, PMID: 9620804]. It is a multi-functional protein whose function depends on its protein partners and post-translational modifications [PMID: 25165434]. Mecp2 is required for proper mitotic spindle organisation [PMID: 25527496] and affects proliferation and apoptosis [PMID: 25227661]. Mutations in MeCP2 gene cause an X-linked neurodevelopmental disease known as Rett syndrome [PMID: 11738839].

GO terms

Biological Process

GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0045892 negative regulation of transcription, DNA-templated

Molecular Function

GO:0010385 double-stranded methylated DNA binding
GO:0042826 histone deacetylase binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF