Heterogeneous nuclear ribonucleoprotein C (IPR017347)

Short name: hnRNP_C

Overlapping homologous superfamilies


Family relationships



This entry represents heterogeneous nuclear ribonucleoproteins C and C-like. The physiologically active form of human heterogeneous nuclear ribonucleoprotein C (hnRNPC) is a tetramer of isoforms hnRNPC1 and C2. It binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single hnRNPC tetramers bind 230-240 nucleotides. It may play a role in the early steps of spliceosome assembly and pre-mRNA splicing. It interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules [PMID: 8264621, PMID: 7567451, PMID: 12509468, PMID: 16010978].

Among the hnRNP C-like proteins is Raly, a protein described in mouse and humans [PMID: 10500250].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.