Membrane cofactor protein CD46 (IPR017341)

Short name: CD46

Overlapping homologous superfamilies

Family relationships



This entry represents a group of membrane cofactor proteins (also known as CD46 or TLX). Human CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue [PMID: 10843656]. Rat CD46 may be involved in the fusion of the spermatozoa with the oocyte during fertilization [PMID: 15215199].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0009986 cell surface

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.