Eukaryotic translation initiation factor 3 subunit G (IPR017334)

Short name: eIF3_g

Overlapping homologous superfamilies


Family relationships



At least eleven different protein factors are involved in initiation of protein synthesis in eukaryotes. Binding of initiator tRNA and mRNA to the 40S subunit requires the presence of the translation initiation factors eIF-2 and eIF-3, with eIF-3 being particularly important for 80S ribosome dissociation and mRNA binding [PMID: 1742346]. eIF-3 is the most complex translation inititation factor, consisting of about 13 putative subunits and having a molecular weight of between 550 - 700 kDa in mammalian cells. Subunits are designated eIF-3a - eIF-3m; the large number of subunits means that the interactions between the individual subunits that make up the eIF-3 complex are complex and varied [PMID: 8995409]. Subunit G is required for eIF3 integrity.

Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [PMID: 8995409, PMID: 15904532]. eIF3g can bind 18S rRNA [PMID: 10085088].

In Drosophila spp. there are two G subunits, known as G-1 and G2.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003743 translation initiation factor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.