Receptor-interacting serine/threonine-protein kinase 2 (IPR017322)

Short name: Rcpt-int_Ser/Thr_kinase-2

Overlapping homologous superfamilies

Family relationships



This entry represents receptor-interacting serine/threonine-protein kinase 2 (RIP2), which functions in the phosphorylation (EC: of its protein target. This enzyme activates pro-caspase-1 and pro-caspase-8, and it thought to potentiate CASP8-mediated apoptosis [PMID: 17186025]. It also activates NF-kappa-B. RIP2 undergoes autophosphorylation; it is phosphorylated upon DNA damage, probably by ATM or ATR.

GO terms

Biological Process

GO:0043065 positive regulation of apoptotic process

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.