Neuronal migration protein doublecortin, chordata (IPR017302)

Short name: Doublecortin_chordata

Overlapping homologous superfamilies


Family relationships



Neuronal migration protein doublecortin (DCX; also known as Lissencephalin-X) seems to be required for the initial steps of neuronal dispersion and cortex lamination during cerebral cortex development [PMID: 18231966]. This protein may act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein, and thereby participate in a signalling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. It may also be involved with LIS-1 in an overlapping, but distinct, signalling pathways that promotes neuronal migration. Defects in neuronal migration protein doublecortin are the cause of lissencephaly X-linked type 1 (LISX1), a classic lissencephaly characterised by mental retardation and seizures that are more severe in male patients [PMID: 9489699, PMID: 9489700].

This family represents the neuronal migration protein doublecortin found in chordates.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.