Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 (IPR017300)

Short name: NHERF-1/NHERF-2

Overlapping homologous superfamilies

Family relationships


This entry includes NHERF-1 and NHERF-2. They are PDZ domain-containing protein that functions as a scaffolding protein for the glutamate transporter GLAST. NHERF1 interacts with GLAST during ER export, while NHERF2 interacts with GLAST in the secretory pathway from the ER-Golgi intermediate compartment to the plasma membrane [PMID: 23200831].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0060090 molecular adaptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.