Family

TIR domain-containing adapter molecule 1 (IPR017278)

Short name: TICAM1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

TIR domain-containing adapter molecule 1 (TICAM1) is involved in innate immunity against invading pathogens. It is an adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis [PMID: 12471095, PMID: 12539043].

GO terms

Biological Process

GO:0045087 innate immune response

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PIRSF