TIR domain-containing adapter molecule 1 (IPR017278)

Short name: TICAM1

Family relationships



TIR domain-containing adapter molecule 1 (TICAM1) is involved in innate immunity against invading pathogens. It is an adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis [PMID: 12471095, PMID: 12539043].

GO terms

Biological Process

GO:0045087 innate immune response

Molecular Function

GO:0004871 signal transducer activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.