Apoptotic protease-activating factor 1 (IPR017251)

Short name: Apaf-1

Overlapping homologous superfamilies

Family relationships



Apoptotic protease activating factor-1 (Apaf-1) is a component protein of the apoptosome [PMID: 24651435]. During apoptosis, cytochrome c is released from mitochondria to the cytosol and binds Apaf-1. Binding of cytochrome c to Apaf-1 allows the recruitment and activation of caspase-9 within the apoptosome [PMID: 18439902].

GO terms

Biological Process

GO:0097190 apoptotic signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0043293 apoptosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.