Histone deacetylase complex, SAP18 subunit (IPR017250)

Short name: Hist_deAcase_cplx_SAP18

Overlapping homologous superfamilies


Family relationships


Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A-histone deacetylase (HDAC) co-repressor complex consists of multiple proteins and regulates gene expression by deacetylating histones.

This group represents the histone deacetylase complex subunit SAP18 (Sin3A associated protein 18) [PMID: 9150135].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.