Snapin (IPR017246)

Short name: Snapin

Overlapping homologous superfamilies


Family relationships


Snapin is a component of the biogenesis of lysosomal organelles complex-1 (BLOC-1), a complex required for the normal biogenesis of lysosome-related organelles, such as melanosomes and platelet dense granules [PMID: 15102850], and endosomal cargo sorting [PMID: 17182842].

Snapin binds to SNAP-25, part of the SNARE complex that mediates the synaptic vesicle docking and fusion [PMID: 10195194]. Snapin may modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25 [PMID: 10195194]. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis [PMID: 11283605, PMID: 12887314]. It may also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells [PMID: 19168546].

GO terms

Biological Process

GO:0006886 intracellular protein transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031083 BLOC-1 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.