Peptidase S54, rhomboid, metazoan (IPR017213)

Short name: Peptidase_S54_rhomboid_met

Overlapping homologous superfamilies

Family relationships


This entry represents metazoan rhomboid proteins (EC:, integral membrane proteins thought to be involved in regulated intra-membrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors [PMID: 17114579]. Rhomboid proteins cleave type-1 transmembrane domains using a catalytic triad composed of serine, histidine and asparagine contributed by different transmembrane domains. These proteins belong to the S54 peptidase family of proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.