Family

DNA (cytosine-5)-methyltransferase 1, eukaryote (IPR017198)

Short name: DNA_C5-MeTrfase_1_euk

Family relationships

Description

This entry represents DNA (cytosine-5)-methyltransferase 1 (Dnmt1; EC:2.1.1.37), which methylates CpG residues, with a preference for hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Dnmt1 mediates transcriptional repression (silencing) by establishing a repressive transcription complex where the N terminus of Dnmt1 binds to HDAC2 (histone deacetylase-2) as well as to DMAP1 (Dnmt1-associated protein) [PMID: 10888872]. LSH, which is related to the SNF2 chromatin-remodelling ATPases, is also required for efficient DNA methylation [PMID: 1796789].

GO terms

Biological Process

GO:0090116 C-5 methylation of cytosine

Molecular Function

GO:0003886 DNA (cytosine-5-)-methyltransferase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF