Junctophilin (IPR017191)

Short name: Junctophilin

Overlapping homologous superfamilies


Family relationships



This entry includes junctophilin 1-4 from animals.

Junctophilins (JPHs) are junctional membrane complex (JMC)-associated proteins found in all excitable cells from striated muscle to neurons. They contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. They provide a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels [PMID: 12729900]. They contain several specific domains, including eight amino-terminal membrane occupation and recognition nexus (MORN) motifs separated by a joining region, followed by an alpha helix, divergent, and a C-terminal transmembrane motif that anchors the protein into the endoplasmic reticulum (ER) or sarcoplasmic reticulum (SR) [PMID: 24636942].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030314 junctional membrane complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.