Spastin (IPR017179)

Short name: Spastin

Overlapping homologous superfamilies


Family relationships


Spastin is an ATP-dependent microtubule severing protein. Microtubule severing may promote reorganisation of cellular microtubule arrays and the release of microtubules from the microtubule organising centre following nucleation [PMID: 11809724, PMID: 12676568, PMID: 15716377].

In humans, defects in spastin are the cause of spastic paraplegia autosomal dominant type 4 (SPG4). Spastic paraplegia is a neurodegenerative disorder characterised by a slow, gradual, progressive weakness and spasticity of the lower limbs [PMID: 10610178, PMID: 11809724].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008568 microtubule-severing ATPase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.